CD 4 + FoxP 3 + CD 73 + regulatory T cell promotes cardiac healing 1 post-myocardial infarction 2 Running title : Zhuang et al . ; CD 73 + Treg promotes cardiac healing 3

1 Department of Cardiovascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, 8 Shanghai, 200120, China 9 2 Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of 10 Medicine, Shanghai, 200120, China 11 3 Institute of Integrated Traditional Chinese and Western Medicine for Cardiovascular Chronic 12 Diseases, Tongji University School of Medicine, Shanghai, 200120, China 13 4 Shanghai Heart Failure Research Center, Shanghai, 200120, China 14 5 Department of Cardiology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 15 200120, China 16 6 Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao 17 Tong University School of Medicine, Shanghai, China 18 7 Department of Child Internal Medicine, Shanghai Children’s Medical Center, Shanghai Jiaotong 19 University, Shanghai 200127, China 20 8 Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, Tongji University, 21 Shanghai 200120, China 22 9 Shanghai Institute of Stem Cell Research and Clinical Translation, Shanghai 200120, China 23 24 * Dr. Zhuang and Dr. Meng contributed equally to this work 25 # To whom correspondence should be addressed: 26 Xiaohui Zhou, M.D., Ph.D. 27 Research Center for Translational Medicine, 28 Shanghai East Hospital, Tongji University School of Medicine 29 150 Jimo Rd, Pudong, Shanghai, 200120, China 30 ORCID: 0000-0002-9354-3789 31 Tel:86-21-61569884 32 E-mail: zxh100@tongji.edu.cn 33 34 Zhongmin Liu, M.D., Ph.D. 35 Research Center for Translational Medicine, 36 Department of Cardiovascular Surgery, 37 Shanghai East Hospital, Tongji University School of Medicine 38 150 Jimo Rd, Pudong, Shanghai, 200120, China 39 E-mail: liu.zhongmin@tongji.edu.cn 40 41