The association between diabetes and Alzheimer’s disease pathophysiology

Veerle van Gils,Stephanie JB Vos,Willemijn J Jansen,Pablo Martinez‐Lage,Jakub Hort,Inez HGB Ramakers, Hilkka Soininen,Markku Laakso,Henrik Zetterberg,Søren Dalsgaard,Frans RJ Verhey,Pieter Jelle Visser

Alzheimer's & Dementia（2021）

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摘要

Diabetes is common in persons with dementia and associated with cognitive decline. However, the relation between diabetes and AD pathophysiology is still unclear. Our aim is to assess the association of diabetes diagnosis and blood glucose regulation with CSF AD biomarkers across the AD clinical spectrum, and the potential moderating effects of vascular factors in this relationship.

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