Matrix metalloproteinases and their tissue inhibitors in heart failure

The integrityof the extracellular matrix is maintained by a balanced interaction between the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs). In heart failure the levels of MMPs and TIMPs are altered resulting in an imbalance. MMPs and TIMPs contribute to various aspects of cardiac remodeling and function. In the present review the contribution of MMPs and TIMPs to the development and progression of cardiac diseases will be discussed. ! 2013 Trade Science Inc. INDIA