OUP accepted manuscript

Undiagnosed asymptomatic subclinical tuberculosis (TB) remains a significant threat to global TB control and accounts for a substantial proportion of cases among people living with HIV/AIDS (PLWHA). We determined the incidence, progression, and outcomes of subclinical TB in anti-retroviral therapy (ART) accessing PLWHA with known previous TB in South Africa.A total of 402 adult PLWHA previously treated for TB were enrolled in the prospective CAPRISA TRuTH (TB Recurrence Upon TB and HIV treatment) study. Participants were screened for TB with quarterly clinical and bacteriologic evaluation and bi-annual chest radiographs over 36 months. Those with suspected or confirmed TB were referred to the National TB Programme. Participants received HIV services, including ART. Incidence rate of TB was estimated by Poisson regression, and descriptive statistical analyses summarised data.A total of 48/402 (11.9%) bacteriologically confirmed incident recurrent TB cases was identified, comprising 17/48 (35.4%) subclinical TB cases and 31/48 (64.5%) clinical TB cases. Age, sex, and body mass index (BMI) were similar among subclinical , clinical , and no TB groups. Incidence rates of recurrent TB overall; in clinical TB; and subclinical TB groups was 2.3 [95% CI: 1.7-3.0]; 1.5 [95% CI: 1.1-2.2]; and 0.9 [95% CI: 0.5-1.4] per 100 person-years, respectively. In the subclinical TB group, 14/17 (82.4%) was diagnosed by TB culture only, 11/17 (64.7%) received TB treatment, and 6/17 (35.3%) resolved TB spontaneously.The high incidence rates of recurrent subclinical TB in PLWHA highlight inadequacies of symptom-based TB screening in high TB-HIV burden settings.