Parthenolide reverses the epithelial to mesenchymal transition process in breast cancer by targeting TGFbeta1: In vitro and in silico studies

Hazera Binte Sufian,Julianna Maria Santos,Zeina S Khan,Sobia Ahsan Halim,Ajmal Khan,Maliha Tabassum Munir,Md Khurshidul Zahid,Ahmed Al-Harrasi,Lauren S Gollahon,Fazle Hussain,Shaikh Mizanoor Rahman

Life Sciences（2022）

引用 6|浏览3

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摘要

•PTL inhibits the migration of both MCF-7 and MDA-MB-231 breast cancer cells.•PTL induces apoptosis in both breast cancer cell lines.•PTL reverses the EMT process by reducing TWIST1 and TGFβ1 gene expression.•Molecular docking studies confirm that PTL binds with TGFβ1.

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关键词

ERα,EMT,MTT,TGFβ1,TAZ,YAP,ROS,GM-CSF

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