Ambient particulate matter exposure plus a high-fat diet exacerbate renal injury by activating the NLRP3 inflammasome and TGF-β1/Smad2 signaling pathway in mice

Jinjin Jiang,Shibin Ding,Guofu Zhang, Yaqi Dong

Ecotoxicology and Environmental Safety（2022）

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摘要

•Ambient particulate matter exposure plus a high-fat diet exacerbated renal injury.•Ambient PM exposure activated the NLRP3 inflammasome in kidney.•Ambient particulate matter exposure plus a high-fat diet exacerbated renal fibrosis via activating the NLRP3 inflammasome.

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关键词

HFD,FA,PM,PM2.5,CKD,IL-1β,IL-6,TNF-α,BUN,TGF-β1,NLRP3,ASC

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