P236. Immunometabolic Signatures in Monocytes Are Associated with Anhedonia in Depressed Patients with High Inflammation

Mandakh Bekhbat,G. Bengu Ulukaya,Paula-Dene C. Nesbeth,Manoj K. Bhasin,Jessica A. Alvarez,Andrew H. Miller,Jennifer C. Felger

Biological Psychiatry（2022）

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摘要

Inflammation is one pathophysiologic pathway implicated in major depression (MD), particularly symptoms of anhedonia. However, little is known about the specific immune cells and intracellular mechanisms that are involved.

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关键词

Major Depressive Disorder (MDD), Anhedonia, Single-cell RNA-seq, Immunometabolism, Monocyte

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