Fucoidan alleviates the mitochondria and endoplasmic reticulum stresses in ischemic rat livers

Chérifa Slim, Hana Nassrallah,Mohamed Amine Zaouali, Fatma Amara,Hatem Majdoub,Didier Morin,Hassen Ben Abdennebi

Phytomedicine Plus（2022）

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摘要

•Fucoidan maintains cell survival.•Fucoidan modulates the phosphorylation of AKT and AMPK and ER stress.•Fucoidan protects mitochondria and reduced oxidative stress and apoptosis.•Fucoidan improves the preservation of hepatic grafts.

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关键词

Liver,Ischemia-reperfusion injury,Fucoidan,TUDCA,Endoplasmic reticulum stress,Mitochondria

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