A novel oncolytic virus induces a regional cytokine storm and safely eliminates malignant ascites of colon cancer.
Cancer medicine（2022）
摘要
OH2 could safely eliminate malignant ascites of colon cancer and convert the cold immune microenvironment by inducing a remarkably regional cytokine storm in ascites, mainly IL-6, in the early stage of antitumor immune responses beyond directed oncolytic virotherapy.
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关键词
colon cancer,cytokine,herpes simplex virus type 2,malignant ascites
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