Does stereotactic body radiation improve outcomes compared to conventional radiation for liver cancer patients?

•There has been a paradigm shift to SBRT without evidence that these high-dose ultra-low fractions result in improved outcomes.•This prospective cohort compares the survival of patients treated with conventional versus SBRT treatments for liver tumours.•The SBRT group received an average of 5 fractions, and the conventional group received an average of 17 fractions.•397 patients were included. Overall survival was higher for SBRT patients at the 2-year time point (42% vs 27% p = 0.01).