p-Hydroxybenzoic acid alleviates inflammatory responses and intestinal mucosal damage in DSS-induced colitis by activating ERβ signaling

Xiaotian Xu,Ailin Luo,Xi Lu,Meng Liu,Huideng Wang,Hengzhi Song,Chengqiong Wei,Yuhui Wang,Xiaoqun Duan

Journal of Functional Foods（2021）

引用 9|浏览3

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摘要

•p-hydroxy benzaldehyde (HD) exerted anti-colitis effects through its metabolite.•p-hydroxybenzoic acid (HA) was identified as the active metabolite of p-hydroxy benzaldehyde responsible for anti-UC activity.•HA could improve colitis by inhibiting inflammatory response and repairing the intestinal barrier via ERβ.

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关键词

Ulcerative colitis,P-hydroxybenzoic acid,Inflammatory response,Intestinal mucosal damage,Estrogen receptor β

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