Synthesis and photodynamic effect of 3-substituted methyl pyropheophorbide-a derivatives as novel photodynamic therapeutic agents for cancer treatment

Tae Heon Lee, Hye Jeong Kim,Bo-Ra Lee,Sang Bong Lee,Da-Sol Lee,Ye Ri Han,Kil Soo Kim,Young Kyu Song,Young Key Shim, Su-Jin Park, Dong-Won Kim,Yong Hyun Jeon

Journal of Industrial and Engineering Chemistry（2022）

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摘要

3-Substituted methyl pyropheophorbide-a derivatives as new PDT agents were developed. Their therapeutic potential was demonstrated in vitro and in vivo.

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关键词

Methyl pyropheophorbide-a (MPPa),Fluorescence dye,Photodynamic therapy (PDT),Tumor targeted imaging,Theranostics

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