Lifetime attributable risk of radiation induced second primary cancer from scattering and scanning proton therapy – A model for out-of-field organs of paediatric patients with cranial cancer

Mikaela Dell'Oro,Michala Short,Puthenparampil Wilson,Dylan Peukert,Chia-Ho Hua,Thomas E. Merchant,Eva Bezak

Radiotherapy and Oncology（2022）

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摘要

•CT dataset-based phantoms were used to investigate radiation induced SPC.•LAR reduced for scanning beam PT compared to scattering (lung, breast and thyroid).•Not all out-of-field organs had improved LAR using scanning PT for younger patients.•Younger female cranial paediatric patients had a higher risk of LAR.

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关键词

Childhood cancer,Second primary cancer,Proton therapy,Organ-specific,Lifetime attributable risk,SPC,LAR

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