Pain pupillary index to prognosticate unfavorable outcome in comatose cardiac arrest patients
Resuscitation(2022)
摘要
Background
The prognostic role of the Pupillary Pain Index (PPI), derived from automated pupillometry, remains unknown in post-anoxic brain injury.
Methods
Single-center retrospective study in adult comatose cardiac arrest (CA) patients. Quantitative PPI and Neurologic Pupil Index (NPi) were concomitantly recorded on day 1 and day 2 after CA. The primary outcome was to assess the prognostic value of PPI to predict 3-month unfavourable outcome (UO, defined as Cerebral Performance Category of 3–5). Secondary outcome was the agreement between PPI and NPi to predict unfavourable outcome.
Results
A total of 102 patients were included; patients with UO (n = 69, 68%) showed a lower NPi (4.2 [3.5–4.5] vs. 4.6 [4.3–4.7]; p < 0.01 on day 1–4.3 [3.8–4.7] vs 4.6 [4.3–4.8] on day 2), and PPI (3 [1–6] vs. 6 [3–7]; p < 0.01 on day 1–3 [1–6] vs 6 [4–8]; p < 0.01 on day 2) than others. A PPI = 1 on day 2 showed a sensitivity of 26 [95% CI 16–38]% and a specificity of 100 [95% CI 89–100]% to predict UO (p = 0.003 vs. NPi ≤ 2). On day 2, a total of 6 patients had concomitant PPI = 1 and NPi ≤ 2, while 12 showed NPi > 2 and PPI = 1; the coefficient of agreement was 0.42. Moreover, NPi and PPI values showed a moderate correlation both on day 1 and day 2.
Conclusions
In this study, PPI = 1 on day 2 could predict UO in comatose CA patients with 100% specificity, but with a low sensitivity (yet higher than NPi). The agreement between PPI and NPi values was moderate.
更多查看译文
关键词
Pupillometry,Prognostication,Heart arrest,Brain injury
AI 理解论文
溯源树
样例
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要