The Association of Excess Body Weight with Risk of ESKD Is Mediated Through Insulin Resistance, Hypertension, and Hyperuricemia.

Josef Fritz,Wolfgang Brozek,Hans Concin,Gabriele Nagel,Julia Kerschbaum,Karl Lhotta,Hanno Ulmer,Emanuel Zitt

Journal of the American Society of Nephrology : JASN（2022）

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摘要

TyG index, MAP, and UA, but not TC, mediate the association of BMI with ESKD in middle-aged adults. Our findings highlight that in addition to weight reduction, the control of metabolic risk factors might be essential in mitigating the adverse effects of BMI on kidney function.

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关键词

blood pressure,body mass index,causal model,dialysis,end-stage kidney disease,insulin resistance,mediation,obesity,triglyceride-glucose index,uric acid

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