Acute concomitant glucose‐dependent insulinotropic polypeptide receptor antagonism during glucagon‐like peptide 1 receptor agonism does not affect appetite, resting energy expenditure or food intake in patients with type 2 diabetes and overweight/obesity

Signe Stensen,Liva L. Krogh,Alexander H. Sparre‐Ulrich,Flemming Dela,Bolette Hartmann,Tina Vilsbøll,Jens J. Holst,Mette M. Rosenkilde,Mikkel B. Christensen,Lærke S. Gasbjerg,Filip K. Knop

Diabetes, obesity & metabolism（2022）

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摘要

During short term infusion, we found no effect of GIPR antagonism added to GLP-1R agonism on appetite sensations, REE, SAT triglyceride content or food intake in patients with type 2 diabetes and overweight/obesity. This article is protected by copyright. All rights reserved.

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关键词

GIP, GIP receptor antagonist, GLP-1, incretin hormones, incretins, obesity, type 2 diabetes

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