Hydrogen sulfide alleviates particulate matter-induced emphysema and airway inflammation by suppressing ferroptosis

Ying Wang,Sha Liao,Zihan Pan,Simin Jiang, Jing Fan,Siwang Yu,Lixiang Xue,Jianling Yang,Shaohua Ma, Tong Liu,Jing Zhang,Yahong Chen

Free Radical Biology and Medicine（2022）

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摘要

Schematic representation of the mechanism of hydrogen sulfide (H2S) against PM2.5- mediated ferroptotic responses in airway epithelial cells. H2S inhibits ferritinophagy signaling via activating Nrf2 and PPAR-γ, in turn suppresses the process of ferroptosis.Image 1

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关键词

Hydrogen sulfide,Chronic obstructive pulmonary disease,PM2.5,Lipid peroxidation,Nrf2,PPAR-γ,Ferritinophagy,Ferroptosis

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