Crocin ameliorates depressive-like behaviors induced by chronic restraint stress via the NAMPT-NAD+-SIRT1 pathway in mice

Feng Zhang,Xinying Zhu,Ping Yu, Tingna Sheng, Yuqing Wang,Yilu Ye

Neurochemistry International（2022）

引用 13|浏览2

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摘要

•Chronic restraint stress (CRS) induces depressive-like behaviors in mice.•Exposure to CRS increases corticosterone level and decreases the expression of DA, 5-HT in PFC, but have no effect on NE.•The contents of NAMPT, SIRT1, NAD+, pCREB/CREB and BDNF in PFC decreased significantly in CRS mice.•Crocin regulates NAMPT-NAD+-SIRT1 signaling pathway.•Crocin improves anxiety, depressive-like behaviors and cognitive function.

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关键词

Crocin,Depression,Chronic restraint stress (CRS),Nicotinamide phosphoribosyltransferase (NAMPT),Nicotinamide adenine dinucleotide (NAD+)

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