Experiences of ethnic discrimination and COMT rs4680 polymorphism are associated with depressive symptoms in Latinx adults at risk for cardiovascular disease

•Findings from this study provide evidence that experiences of ethnic discrimination are associated with increased depressive symptoms in Latinx adults.•Findings from this study demonstrate the rs4680 SNP to be associated with depressive symptoms in Latinx adults, with having one or two Met-alleles associated with increased depressive symptoms.•This understanding can lead to a greater awareness among health care providers of life stressors that may predispose Latinx adults to depressive symptoms, and subsequently CVD.