Bombesin receptor-activated protein exacerbates cisplatin-induced AKI by regulating the degradation of SIRT2.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association(2022)

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摘要
Our results demonstrated that BRAP played an important role in tubular cell apoptosis and necroptosis during CP-induced AKI. Safe and efficient BRAP inhibitors might be effective therapeutic options for AKI.
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关键词
AKI,BRAP,SIRT2,apoptosis,necroptosis,ubiquitination
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