Anticoagulation as secondary prevention of massive lung thromboses in hospitalized patients with COVID-19

•COVID-19 related thrombosis are immune-mediated and detectable as lung MicroCLOTS.•COVID-19 radiological pattern confirms that in situ thrombosis are not embolisms.•Full anticoagulation may prevent MicroCLOTS in non-ICU COVID-19 patients.•Routine full anticoagulation might increase bleeding risk in advanced stages.•Anti-inflammatory drugs play a pivotal role in the management of MicroCLOTS.