Retinal Neuroprotective Effect of Mesenchymal Stem Cells Secretome Through Modulation of Oxidative Stress, Autophagy, and Programmed Cell Death.

Ricardo Usategui-Martín,Kevin Puertas-Neyra,Nadia Galindo-Cabello,Leticia A Hernández-Rodríguez,Fernando González-Pérez,José Carlos Rodríguez-Cabello,Rogelio González-Sarmiento,José Carlos Pastor,Ivan Fernandez-Bueno

Investigative ophthalmology & visual science（2022）

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摘要

The neuroprotective ability of the bmMSC secretome is associated with activation of antioxidant machinery, modulation of autophagy, and inhibition of apoptosis and necroptosis during retinal degeneration. The neuroprotective effect of bmMSC secretomes in the presence/absence of MSC looks similar. Our current results reinforce the hypothesis that the human bmMSC secretome slows retinal neurodegeneration and may be a therapeutic option for treating RND.

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关键词

retina, cell therapy, neurodegeneration, neuroprotection, oxidative stress, programmed cell death

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