Follistatin-related protein 1 in asthma: miR-200b-3p interactions affect airway remodeling and inflammation phenotype

••FSTL1 and miR-200b-3p are identified to be candidate interacting participants in airway epithelium during asthma progression.••TGF-β1 exposure reduces miR-200b-3p expression in BEAS-2B cells.••MiR-200b-3p directly targets FSTL1 and inhibits BEAS-2B cell remodeling.••LncRNA PCAT19 upregulates FSTL1 expression in airway epithelium through ceRNA mechanisms.••MiR-200b-3p overexperssion attenuates the airway inflammation, mucus hypersecretion, and remodeling in experimental asthma.