Liproxstatin-1 alleviates LPS/IL-13-induced bronchial epithelial cell injury and neutrophilic asthma in mice by inhibiting ferroptosis

•Ferroptosis occurred in the lung of mice suffering OVA/LPS-induced neutrophilic asthma.•Liproxstatin-1 alleviated neutrophilic asthma in mice by inhibiting ferroptosis.•Liproxstatin-1 could prevent LPS/IL-13-induced ferroptosis and inflammatory factor release in HBE and BEAS-2B cells.•Liproxstatin-1 inhibited ferroptosis in asthmatic mice lung tissues and bronchial epithelial cells via the GPX4/SLC7A11 pathway.