Predictive metabolic networks reveal sex- and APOE genotype-specific metabolic signatures and drivers for precision medicine in Alzheimer's disease.

Rui Chang,Eugenia Trushina,Kuixi Zhu,Syed Shujaat Ali Zaidi,Branden M Lau,Alexandra Kueider-Paisley,Sara Moein,Qianying He,Melissa L Alamprese,Barbora Vagnerova,Andrew Tang,Ramachandran Vijayan,Yanyun Liu,Andrew J Saykin,Roberta D Brinton,Rima Kaddurah-Daouk

Alzheimer's & dementia : the journal of the Alzheimer's Association（2023）

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摘要

These findings provide an initial but critical step in developing a diagnostic platform for personalized medicine by integrating metabolomic profiling and cognitive assessments to identify targeted precision therapeutics for AD patient subgroups through computational network modeling.

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关键词

Alzheimer's Disease Neuroimaging Initiative,apolipoprotein E ε4,computational systems biology,late-onset Alzheimer's disease,metabolic biomarkers,metabolic network,metabolomics,precision medicine,sex-specific metabolic changes

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