Tolerability and feasibility of at-home remotely supervised transcranial direct current stimulation (RS-tDCS): Single-center evidence from 6,779 sessions

•Remotely supervised (RS-tDCS) is established for at-home tDCS in clinical trials.•We analyzed 6779 RS-tDCS sessions in 308 participants across Class I/II/III trials.•RS-tDCS is tolerable and feasible over extended and repeated applications.•Use of at-home RS-tDCS supports feasibility and scalability for RCTs.•Home-based tDCS provides a solution to complete Class I trial designs.