Palmitoylethanolamide ameliorates neuroinflammation via modulating PPAR-α to promote the functional outcome after intracerebral hemorrhage

Guoyang Zhou,Xiongjie Fu,Liang Wang,Yang Cao,JianFeng Zhuang,Junwen Hu,Yin Li,Chaoran Xu,Shiqi Gao,Anwen Shao,Lin Wang

Neuroscience Letters（2022）

引用 5|浏览21

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摘要

•PEA can improve neurological and motor function after ICH.•PEA treatment ameliorates ICH-induced neuroinflammatory injury.•PEA promotes the shift in the polarization of microglia from M1 to M2 phenotypes.•PPAR-α participated in the anti-inflammatory effect of PEA on BV2 cell after ICH.

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关键词

Intracerebral hemorrhage,Palmitoylethanolamide,PPAR-α,NF-kB,Neuroinflammation

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