Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents pulmonary GVHD suppressing perivenulitis and bronchiolitis

Hiroyuki Muranushi,Takero Shindo,Toyofumi F Chen-Yoshikawa,Akihiko Yoshizawa, Huong Thi Ngo, Fumiaki Gochi,Hiroshi Date,Akifumi Takaori-Kondo

Blood Advances（2022）

引用 3|浏览11

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摘要

•Bronchiolitis and perivascular inflammation with phosphorylation of ERK1/2 and AKT within lymphocytes characterize human pGVHD.•Dual inhibition of the MEK/ERK and PI3K/AKT pathways prevents bronchiolitis and perivascular inflammation in murine pGVHD.

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