Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor
Duncan C. Miller,Tristan Reuillon,Lauren Molyneux,Timothy Blackburn,Simon J. Cook,Noel Edwards,Jane A. Endicott,Bernard T. Golding,Roger J. Griffin,Ian Hardcastle,Suzannah J. Harnor,Amy Heptinstall,Pamela Lochhead,Mathew P. Martin,Nick C. Martin,Stephanie Myers,David R. Newell,Richard A. Noble,Nicole Phillips,Laurent Rigoreau,Huw Thomas,Julie A. Tucker,Lan-Zhen Wang,Michael J. Waring,Ai-Ching Wong,Stephen R. Wedge,Martin E. M. Noble,Celine Cano JOURNAL OF MEDICINAL CHEMISTRY（2022）
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ERK pathway,Drug Target Identification
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