Arsenic trioxide induces the differentiation of retinoic acid-resistant neuroblastoma cells via upregulation of HoxC9.

Chunmou Li,Chuchu Feng,Yantao Chen,Pingping Wu,Peng Li,Xilin Xiong,Xiaomin Peng,Zhixuan Wang,Yang Li

Advances in clinical and experimental medicine : official organ Wroclaw Medical University（2022）

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摘要

Arsenic trioxide may reactivate the expression of HoxC9 by downregulating EZH2, which leads to restoring RA sensitivity and promoting the differentiation and apoptosis of RA-resistant NB cells.

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关键词

EZH2 gene,HoxC9 promoter,arsenic trioxide,neuroblastoma,retinoic acid resistance

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