Disrupted-in-schizophrenia 1 Protein Misassembly Impairs Cognitive Flexibility and Social Behaviors in a Transgenic Rat Model

An-Li Wang,Owen Y Chao,Susanne Nikolaus,Valeria Lamounier-Zepter,Cornelis P Hollenberg,Gert Lubec,Svenja V Trossbach,Carsten Korth,Joseph P Huston

Neuroscience（2022）

引用 2|浏览13

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摘要

•In water maze tasks, tgDISC1 rats were deficient in flexible adaptation.•tgDISc1 rats displayed less social interaction.•DISC1 gene overexpression impairs cognitive flexibility and social behaviors.

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关键词

schizophrenia,DISC1 gene overexpression,social behavior,stress,cognitive flexibility

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