Xueshuantong injection combined with Salvianolate lyophilized injection improves the synaptic plasticity against focal cerebral ischemia/reperfusion injury in rats through PI3K/AKT/mTOR and RhoA/ROCK pathways

Qing Yuan,Fu-Jiang Wang,Zhuang-Zhuang Jia, Tong Zhang, Jin Sun,Xin-Yuan Du,Shao-Xia Wang,Li-Juan Chai,Li-Min Hu

Brain Research（2022）

引用 4|浏览8

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摘要

•1X1S shows multiple-action-multiple-target efficacy for cerebral ischemia.•1X1S improves synaptic plasticity in MCAO/R rats by increasing synaptic proteins.•1X1S promotes synaptic plasticity via PI3K/ AKT/ mTOR and RhoA/ROCK2 pathway.

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关键词

Cerebral ischemia/reperfusion,Synaptic plasticity,Xueshuantong lyophilized injection,Salvianolate lyophilized injection

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