3,3′-Diindolylmethane and 1,4-dihydroxy-2-naphthoic acid prevent chronic mild stress induced depressive-like behaviors in female mice

Caitlin A Madison,Jacob Kuempel,Georgia Lee Albrecht,Lauren Hillbrick,Arul Jayaraman,Stephen Safe,Robert S Chapkin,Shoshana Eitan

Journal of Affective Disorders（2022）

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摘要

•Dietary AhR ligands, such as DIM and 1,4-DHNA, might be potential antidepressants.•DIM and 1,4-DHNA have little to no effects on anxiety levels.•DIM and 1,4-DHNA do not cause spatial learning deficits in Morris water maze task.

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关键词

Depression,Anxiety,Spatial learning,Aryl hydrocarbon receptor (AhR),3,3′-Diindolylmethane (DIM),1,4-Dihydroxy-2-naphthoic acid (1,4-DHNA),3,7-Dihydroxy-2-naphthoic acid (3,7-DHNA)

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