Layer-specific Nos3 expression and genotypic distribution in bicuspid aortic valve aortopathy.

Jennifer C Hill,Marie Billaud,Tara D Richards,Mary P Kotlarczyk,Sruti Shiva,Julie A Phillippi,Thomas G Gleason

European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery（2022）

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摘要

These findings of differential Nos3 in media/intima versus adventitia depending on valve morphology or aneurysm reveal new information regarding aneurysmal pathophysiology and support our ongoing assertion that there are distinct mechanisms giving rise to ascending aortopathy in BAV and TAV patients.

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关键词

Aneurysm,Bicuspid aortic valve,Endothelial cells,Nitric oxide synthase 3,Single-nucleotide polymorphism

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