Phenotypic, transcriptomic and functional profiling reveal reduced activation thresholds of CD8+ T cells in giant cell arteritis.

Rosanne D Reitsema,Kornelis S M van der Geest,Maria Sandovici,William F Jiemy,Jacoba C Graver,Wayel H Abdulahad,Annemieke M H Boots,Peter Heeringa,Elisabeth Brouwer

Rheumatology (Oxford, England)（2022）

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摘要

In GCA, circulating effector memory CD8+ T cells demonstrate a proliferation-prone phenotype. The presence of CD8+ T cells in inflamed arteries seems to reflect recruitment of circulating cells rather than local expansion. CD8+ T cells in inflamed tissues produce IFN-γ, which is an important mediator of local inflammatory responses in GCA.

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关键词

CD8+,GCA,T cells,single-cell RNA sequencing,vasculitis

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