Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma

Koji Itakura,Naoya Fujino,Yosuke Kamide,Ikuo Saito,Mitsuhiro Yamada,Koji Okutomo,Yoko Tsukita,Takuya Saito,Tomohiro Ichikawa,Tadahisa Numakura,Yorihiko Kyogoku,Hiroyuki Aizawa,Yoshinao Ono,Shuichiro Matsumoto,Tracy Hussell,Masami Taniguchi,Masakazu Ichinose,Hisatoshi Sugiura

Allergology International（2022）

引用 3|浏览6

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摘要

Axl kinase expressed by basal cells may suppress excessive eosinophilic inflammation via inhibition of GM-CSF in the airway. Axl reduction has clinical implications for the pathogenesis of severe asthma.

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关键词

Airway,Asthma,Axl receptor tyrosine kinase,Eosinophilic inflammation,Granulocyte-macrophage colony-stimulating factor

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