Stereoselective Synthesis of beta-Glycinamide Ribonucleotide

Lisa Ngu,Debarpita Ray,Samantha S Watson,Penny J Beuning,Mary Jo Ondrechen,George A O'Doherty

MOLECULES（2022）

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摘要

A diastereoselective synthesis of the beta-anomer of glycinamide ribonucleotide (beta-GAR) has been developed. The synthesis was accomplished in nine steps from D-ribose and occurred in 5% overall yield. The route provided material on the multi-milligram scale. The synthetic beta-GAR formed was remarkably resistant to anomerization both in solution and as a solid.

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关键词

beta-glycinamide ribonucleotide, beta-GAR, GART, stereoselective synthesis

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