Simultaneous multifactor Bayesian analysis (SiMBA) of PET time activity curve data

•SiMBA is a pharmacokinetic modelling approach for Positron Emission Tomography data.•It is a multivariate hierarchical implementation of the two-tissue compartment model.•This approach exploits similarities between individuals, regions and parameters.•SiMBA improves quantitative accuracy, but also precision of statistical inferences.