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Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist

Claudia Betschart,Michael Faller,Florence Zink,René Hemmig,Jutta Blank,Eric Vangrevelinghe,Marjorie Bourrel,Ralf Glatthar,Dirk Behnke, Kerstin Barker, Andreas Heizmann,Daniela Angst,Pierre Nimsgern,Sébastien Jacquier,Tobias Junt,Géraldine Zipfel,Giulia Ruzzante,Pius Loetscher,Sarah Limonta,Stuart Hawtin,Cedric Bernard Andre,Thomas Boulay,Roland Feifel,Thomas Knoepfel

ACS MEDICINAL CHEMISTRY LETTERS（2022）

Cited 4|Views23
Key words
Structure-based optimization, TLR7, TLR8, Antagonist
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