Long term survival in patients with human papillomavirus-positive oropharyngeal cancer and equivocal response on 12-week PET-CT is not compromised by the omission of neck dissection

Suyun Zhou, Christopher Chan,Robert Rulach, Hesham Dyab,Fraser Hendry, Carole Maxfield,Mary-Frances Dempsey,Allan James,Derek Grose,Carolynn Lamb,Stefano Schipani,Christina Wilson,Yee Cheng Lau,Claire Paterson

Oral Oncology（2022）

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摘要

•EQR on 12-week PET-CT is a poor predictor of residual disease in HPV-positive HNSCC.•86% of HPV positive equivocal nodal responders had no recurrence on surveillance.•Comparable OS between HPV-positive CR & EQR despite omission of immediate ND in 95%•Supports the safety of further surveillance following 12-week PET-CT for EQR group.

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关键词

Head and neck cancer,Oropharyngeal cancer,Human Papillomavirus,Radiotherapy,Chemotherapy, Neck dissection,PET/CT,Response assessment,Overall survival,Survival outcomes

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