Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease

Aidan J McGlinchey,Olivier Govaere,Dawei Geng,Vlad Ratziu,Michael Allison, Jerome Bousier,Salvatore Petta, Claudia de Oliviera,Elisabetta Bugianesi,Jörn M Schattenberg,Ann K Daly,Tuulia Hyötyläinen,Quentin M Anstee,Matej Orešič

JHEP Reports（2022）

引用 27|浏览8

暂无评分

摘要

•We assembled a highly phenotyped and characterised cohort of patients with NAFLD across the full spectrum of NAFLD.•Lipidomic and metabolomic interrogation of this dataset reveals crucial metabolic tipping point of NAFLD at fibrosis stage F2–F3.•NAFLD processes of fibrosis, steatosis, and NASH progression parallel distinct changes in metabolomic profiles.•Oxidative stress-buffering potential of the liver via ether lipids appears 1 of the key changes en route to late-stage NASH.

查看译文

关键词

Fibrosis,Lipidomics,Mass spectrometry,Metabolomics,Non-alcoholic steatohepatitis

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要