Melatonin restores zinc levels, activates the Keap1/Nrf2 pathway, and modulates endoplasmic reticular stress and HSP in rats with chronic hepatotoxicity.

Silvia Bona,Sabrina Alves Fernandes, Andrea C Janz Moreira,Graziella Rodrigues,Elizângela G Schemitt,Fabio Cangeri Di Naso,Cláudio A Marroni,Norma P Marroni

World journal of gastrointestinal pharmacology and therapeutics（2022）

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摘要

MLT has a hepatoprotective effect in an experimental model of CCl-induced liver injury, since it reduces oxidative stress, restores zinc levels, and modulates endoplasmic reticulum stress.

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关键词

Antioxidant,Carbon tetrachloride,Cell damage,Liver injury,Melatonin

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