LncRNA MIR99AHG enhances adipocyte differentiation by targeting miR-29b-3p to upregulate PPARγ

Lin Zhang,Jinfang Ma,Xiaohui Pan,Mei Zhang,Wei Huang,Yanjun Liu,Huawu Yang,Zhong Cheng,Guixiang Zhang,Mingrong Qie,Nanwei Tong

Molecular and Cellular Endocrinology（2022）

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摘要

•MIR99AHG and miR-29b-3p are selected as the target lncRNA and miRNA during 3T3-L1 preadipocytes differentiation.•Inhibition of MIR99AHG prevents obesity in mice.•MIR99AHG sponges miR-29p-3p to promote PPARγ-mediated regulation of preadipocyte differentiation.

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关键词

MIR99AHG,miR-29b-3p,Adipogenesis,Obesity

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