Polymer microspheres modified with pyrazole derivatives as potential agents in anticancer therapy – Preliminary studies

Beata Podkościelna,Katarzyna Klimek,Zbigniew Karczmarzyk,Waldemar Wysocki,Małgorzata Brodacka, Karolina Serafin,Paweł Kozyra,Dorota Kowalczuk,Grazyna Ginalska,Monika Pitucha

Bioorganic Chemistry（2022）

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摘要

•Crosslinked polymeric microspheres based on divinylbenzene and glycidyl meth-acrylate were functionalized with pyrazole derivatives.•All tested pyrazole derivatives and modified by them polymer microspheres exhibited anti-proliferative activity in vitro.•The molecular docking study using human EphB1 receptor showed that analyzed compounds can link with the binding site of EphB1.

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关键词

Pyrazole,X-ray analysis,Anticancer activity,Copolymer,Molecular docking,human EphB1 receptor

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