Film-like organelles equip cells with multiple genetic codes
Trends in Biochemical Sciences（2022）
摘要
The simultaneous incorporation of distinct noncanonical amino acids into different proteins within eukaryotic cells remains challenging. This new study by Reinkemeierand Lemke demonstrates how 2D phase separation can be used to engineer spatially separated organelles. These film-like organelles translate proteins independently from each other and the canonical genetic code.
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关键词
genetic code expansion,synthetic biology,2D phase separation,noncanonical amino acid,synthetic organelle,enzyme engineering
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