LncRNA SOX2OT facilitates LPS-induced inflammatory injury by regulating intercellular adhesion molecule 1 (ICAM1) via sponging miR-215-5p

•Blocking SOX2OT suppressed oxidative stress and inflammatory response in LPS-treated AC16 cardiomyocytes, accompanied with apoptosis promotion.•Reinforcing miR-215-5p mitigated LPS-induced injuries in AC16 cardiomyocytes.•miR-215-5p was a target of SOX2OT, and further targeted ICAM1 in AC16 cells.•There was a SOX2OT/miR-215-5p/ICAM1 regulatory axis in AC16 cardiomyocytes.