The Genesis of Pain in Osteoarthritis: Inflammation as a Mediator of Osteoarthritis Pain

In the United States, approximately 20% of adults suffer from chronic pain, creating a substantive personal and societal burden and costing the economy up to $635 billion per year.1,2 The musculoskeletal system is one of the leading sources of chronic pain, with osteoarthritis (OA) as the leading cause. As the most prevalent form of arthritis, OA affects over 32.5 million U.S. adults. Worldwide, 240 million individuals live with symptomatic OA,3-6 and its prevalence is increasing as the world's population is