The mechanism of low-dose radiation-induced upregulation of immune checkpoint molecule expression in lung cancer cells

Xinan Wan, Mingxing Fang,Tingting Chen,Huihui Wang, Qin Zhou, Yongming Wei, Lin Zheng, Yu Zhou,Kai Chen

Biochemical and Biophysical Research Communications（2022）

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摘要

•Low dose irradiation can cause the upregulation of PD-L1 and CD47.•Irradiation may regulate the expression of CD47 and PD-L1 through the JAK2/STAT3 pathway.•Irradiation combined with PD-L1/CD47 inhibitor increased the infiltration of CD8-positive T cells.•Low dose irradiation combined with PD-L1/CD47 inhibitor enhanced the inhibition of tumor.

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关键词

Low-dose irradiation,Lung cancer cell,Immune checkpoint molecule,JAK2/STAT3 pathway

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