Recombinant humanized IgG1 maintain liver triglyceride homeostasis through Arylacetamide deacetylase in ApoE−/− mice

Sujun Xiao,Run Lin,Rui Duan,Zhonghao Li,Dongmei Tang,Xianyan Liu,Yan Liu,Ming Zhao

International Immunopharmacology（2022）

引用 5|浏览8

暂无评分

摘要

•Recombinant humanized IgG1 decreased serum level of TG, LDL-C and hepatic TG contents of high-fat diet mice.•Recombinant humanized IgG1 altered hepatic gene expression profiles of high-fat diet mice.•Recombinant humanized IgG1 ameliorated fat deposition by enhancing expression of arylacetamide deacetylase (Aadac).•Recombinant humanized IgG1 regulated expression of Aadac via the FcRn/PKCδ/foxa1/Aadac pathway.

查看译文

关键词

Hyperlipidemia,Triglyceride,Recombinant humanized IgG1,RNA-Seq,Aadac,Foxa1,PKCδ

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要