A novel plant lectin, NTL-125, interferes with SARS-CoV-2 interaction with hACE2

Anindya Sarkar,Sathi Paul,Charandeep Singh,Nilkanta Chowdhury,Papri Nag, Swarnava Das,Sahil Kumar,Anshul Sharma,Deepjyoti Kumar Das,Dipak Dutta,Krishan Gopal Thakur,Angshuman Bagchi,Surbhi Shriti,Kali P. Das,Rajesh P. Ringe,Sampa Das

Virus Research（2022）

引用 5|浏览18

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摘要

•Mannose binding NTL-125 lectin inhibits the virus replication in Vero cell line•Native and mutant spike proteins show higher binding affinity to NTL-125 than the corresponding Spike-hACE2•Higher affinity of NTL-125 to RBD competitively inhibits Spike-hACE2 interaction.•NTL-125 disrupts protective viral shield by interacting with glycan moieties of spike•NTL-125 could be promising therapeutic molecule and or biosensor for COVID-19 detection.

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关键词

Molecular docking,Mutant variants, Narcissus tazetta lectin,SARS-CoV-2,Spike Protein

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